英国剑桥大学2023年招聘博士后职位（心血管再生医学）

英国剑桥大学2023年招聘博士后职位（心血管再生医学）

剑桥大学（University of Cambridge），位于英国剑桥郡，是一所公立研究型大学。

剑桥大学采用传统学院制。学校是罗素大学集团成员，全球大学校长论坛成员，被誉为“金三角名校”、“Doxbridge”、“G5”。剑桥大学是英语世界中第二古老的大学，前身是一个于1209年成立的学者协会。

剑桥大学是英国罗素大学集团、全球大学高研院联盟、金三角名校、国际应用科技开发协作网及剑桥大学医疗伙伴联盟成员，衍育了科技聚集地“硅沼（Silicon Fen）”。设八座文理博物馆，馆藏逾1500万册的图书馆系统及全球最古老的出版社――剑桥大学出版社。

Post-Doctoral Research Associate in Cardiovascular Regenerative Medicine

University of Cambridge

United Kingdom

November 06, 2023

Offerd Salary:£36,024-£44,263

Post-Doctoral Research Associate in Cardiovascular Regenerative Medicine

Applications are invited to join a dynamic team led by Prof Sanjay Sinha (https: // www. sinha-lab.org/ and https: // www. stemcells.cam.ac.uk/people/pi/sinha), to investigate mechanical sensing and mechanical memory in cardiac muscle cells and its involvement in cardiovascular disease.

Cardiovascular diseases are the major cause of mortality worldwide, yet there is still a lack of effective treatments. Recent research increasingly emphasised that changes to mechanical sensing and signalling critically influences the disease onset and progression1-2. Additionally, our recent data indicated that mechanical information is stored at attachment sites between cardiac muscle cells and their extracellular environment3-4. This mechanical memory influences the cellular behaviour and will need to be targeted to effectively treat heart disease. The position will be based at the Sinha lab within the Cambridge Stem Cell Institute at the University of Cambridge, and is part of a recently funded British Heart Foundation Special Project Grant in collaboration with Dr Thomas Iskratsch at Queen Mary University of London and Prof Ben Goult at the University of Kent. Within this consortium one PDRA will be embedded in each group and work together towards the collaborative goal to decipher mechanical memory as driver for cardiac disease progression across the scales from single molecule5 to tissue level6.

The Sinha lab focuses on using pluripotent stem cell-based systems to generate cardiovascular cells including 3D engineered heart tissues6. These will be used to understand the role of mechanical signals and memory in the cardiovascular system at tissue scale, whereas the groups in UKent and QMUL harness their expertise to investigate the processes at single molecule and single cell scale, respectively. To reach the collaborative goals, the teams will be in regular contacts for coordination, exchange of data and resources.

・ Iskratsch et al., Nat Rev Cell Mol Biol (2013)

・ Pandey et al, Dev Cell (2018)

・ Marhuenda et al, BioRxiv (2023)

・ Goult et al, JCS (2021)

・ Gallego-Paez, JCB (2023)

・ Bargehr, Nat Biotech (2019)

About You

The successful candidate will be highly motivated, collaborative and have expertise in pluripotent stem cell biology and cardiac biology. Prior experience in mechanobiology and tissue engineering is highly desirable.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 6th November 2023

The interview date for the role is: To be confirmed

Please quote reference PS38813 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

・ Further ParticularsDepartment/Location

Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute

Salary

£36,024-£44,263

Reference

PS38813

Category

Research

Published

6 October 2023

Closing date

6 November 2023